Scientists discover why cancer therapies not working

The team determined that a key checkpoint in the immune system - called NKG2A - doesn't engage with its specific binding molecule expressed in cancer cells until the appropriate signal is received

New York: Scientists have uncovered a mechanism by which cancer cells prevent the immune system from activating and attacking the cancerous invaders.

The study, published in the journal Cell Reports, sheds light on why immunotherapy treatments don't work for all people or all diseases.

For example, certain types of cancers -- including colon, pancreatic, prostate and brain cancers -- have stubbornly resisted immunotherapy.

And while breast, oesophageal and head and neck cancers often respond favourably, sometimes the treatments don't work as planned. Researchers still don't understand exactly why.

"Immunotherapy is an incredibly promising new treatment avenue for cancer, but we still have work to do determining why it doesn't work for all people or types of cancer," said Jon Weidanz, associate vice president for research and innovation at University of Texas at Arlington.

The team determined that a key checkpoint in the immune system - called NKG2A - doesn't engage with its specific binding molecule expressed in cancer cells until the appropriate signal is received.

"The team reasoned that monotherapy agents targeting the NKG2A receptor may not be effective without receiving an inflammatory trigger," said Soroush Ghaffari, a postdoctoral fellow at the varsity.

"This might explain why drugs designed to bind to the NKG2A receptor to disrupt this immune checkpoint have been only effective when used in combination with other agents that can induce the necessary inflammatory signal," Ghaffari said.

A second major finding of the study revealed how certain cancers can inhibit the immune system from activating its macrophages, which are specialised immune cells that play a critical role in eliminating diseased or damaged cells.